Yifan Zhai Selected Research

olverembatinib

1/2022	FLT3 inhibition by olverembatinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor lisaftoclax (APG-2575) in preclinical models of FLT3-ITD mutant acute myeloid leukemia.
1/2019	Preclinical development of HQP1351, a multikinase inhibitor targeting a broad spectrum of mutant KIT kinases, for the treatment of imatinib-resistant gastrointestinal stromal tumors.

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Yifan Zhai Research Topics

Disease

8	Neoplasms (Cancer) 07/2022 - 04/2003
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 01/2022
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2022 - 01/2019
1	Hematologic Neoplasms (Hematological Malignancy) 01/2022
1	Leukemia 01/2022
1	Colorectal Neoplasms (Colorectal Cancer) 01/2022
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022
1	Retinal Degeneration 10/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 01/2019
1	Adenocarcinoma 05/2018
1	Stomach Neoplasms (Stomach Cancer) 05/2018
1	Breast Neoplasms (Breast Cancer) 04/2003

Drug/Important Bio-Agent (IBA)

3	Tyrosine Kinase InhibitorsIBA 07/2022 - 01/2022
2	osimertinibIBA 07/2022 - 01/2022
2	olverembatinibIBA 01/2022 - 01/2019
2	LisaftoclaxIBA 01/2022 - 01/2022
1	Carboplatin (JM8)FDA LinkGeneric 07/2022
1	ErbB Receptors (EGF Receptor)IBA 07/2022
1	Tetrazolium SaltsIBA 07/2022
1	trametinibIBA 07/2022
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 07/2022
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 07/2022
1	Aldehyde DehydrogenaseIBA 07/2022
1	Paclitaxel (Taxol)FDA LinkGeneric 07/2022
1	Drug CombinationsIBA 07/2022
1	MitogensIBA 07/2022
1	HomoharringtonineIBA 01/2022
1	STAT5 Transcription FactorIBA 01/2022
1	EnzymesIBA 10/2021
1	Heme (Haem)IBA 10/2021
1	Heme Oxygenase-1IBA 10/2021
1	Immune Checkpoint InhibitorsIBA 11/2019
1	pembrolizumabIBA 11/2019
1	Phosphotransferases (Kinase)IBA 01/2019
1	ponatinibIBA 01/2019
1	Imatinib Mesylate (Gleevec)FDA Link 01/2019
1	Sincalide FDA Link 05/2018
1	LigandsIBA 04/2003
1	Glycoproteins (Glycoprotein)IBA 04/2003
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 04/2003

Therapy/Procedure

5	Therapeutics 07/2022 - 05/2018
1	Drug Therapy (Chemotherapy) 05/2018